B 95-8 cell line induced with TPA then stained with monoclonal
antibody to the large subunit of the viral ribonucleotide reductase at different
times after induction. At 24 hours after induction the protein accumulates
in the cytoplasm as seen as granular staining. At 36 hours filamentous
structures are stained, a possible association of the protein with microtubules
of the cell (see electron microscopic pictures). At 48 hours the protein is
present in the cell as large aggregates. For reference see
et al.1987, and Luka et al 1986.
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