B 95-8 cell line induced with TPA then stained with monoclonal antibody to the large subunit of the viral ribonucleotide reductase at different times after induction. At 24 hours after induction the protein accumulates in the cytoplasm as seen as granular staining. At 36 hours filamentous structures are stained, a possible association of the protein with microtubules of the cell (see electron microscopic pictures). At 48 hours the protein is present in the cell as large aggregates. For reference see Goldschmidts et al.1987, and Luka et al 1986.
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